Target Self‐Enhanced Selectivity in Metal‐Specific DNAzymes

Po‐Jung Jimmy Huang, Donatien de Rochambeau, Hanadi F. Sleiman, Juewen Liu


Abstract
The more the merrier: Better selectivity for Zn2+ ions is shown for DNAzymes that bind more metal ions. This selectivity is exemplified by using a series of in vitro selected DNAzymes that contain a single metal ligand modification at the cleavage junction.
Cite:
Po‐Jung Jimmy Huang, Donatien de Rochambeau, Hanadi F. Sleiman, and Juewen Liu. 2020. Target Self‐Enhanced Selectivity in Metal‐Specific DNAzymes. Angewandte Chemie International Edition, Volume 59, Issue 9, 59(9):3573–3577.
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